912517_La Marca,J_2020.pdf (6.36 MB)
Two-Faced: Roles of JNK Signalling During Tumourigenesis in the Drosophila Model
Version 2 2022-11-10, 00:02
Version 1 2020-10-15, 23:13
journal contribution
posted on 2022-11-10, 00:02 authored by John La-MarcaJohn La-Marca, Helena RichardsonHelena RichardsonThe highly conserved c-Jun N-terminal Kinase (JNK) signalling pathway has
many functions, regulating a diversity of processes: from cell movement
during embryogenesis to the stress response of cells after
environmental insults. Studies modelling cancer using the vinegar fly,
Drosophila melanogaster, have identified both pro- and anti-tumourigenic
roles for JNK signalling, depending on context. As a tumour suppressor,
JNK signalling commonly is activated by conserved Tumour Necrosis
Factor (TNF) signalling, which promotes the caspase-mediated death of
tumourigenic cells. JNK pathway activation can also occur via actin
cytoskeleton alterations, and after cellular damage inflicted by
reactive oxygen species (ROS). Additionally, JNK signalling frequently
acts in concert with Salvador-Warts-Hippo (SWH) signalling – either
upstream of or parallel to this potent growth-suppressing pathway. As a
tumour promoter, JNK signalling is co-opted by cells expressing
activated Ras-MAPK signalling (among other pathways), and used to drive
cell morphological changes, induce invasive behaviours, block
differentiation, and enable persistent cell proliferation. Furthermore,
JNK is capable of non-autonomous influences within tumour microenvironments by effecting the transcription of various cell growth-
and proliferation-promoting molecules. In this review, we discuss these
aspects of JNK signalling in Drosophila tumourigenesis models, and
highlight recent publications that have expanded our knowledge of this
important and versatile pathway.
Funding
JL is supported by Australian Research Council (DP170102549) awarded to HR, who is supported by funding from the School of Molecular Sciences, La Trobe University.
History
Publication Date
2020-02-05Journal
Frontiers in Cell and Developmental BiologyVolume
8Article Number
42Pagination
20p.Publisher
Frontiers Media S.A.ISSN
2296-634XRights Statement
© 2020 La Marca and Richardson. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.Publisher DOI
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- Biochemistry and cell biology not elsewhere classified
- Cell development, proliferation and death
- Cellular interactions (incl. adhesion, matrix, cell wall)
- Genetics not elsewhere classified
- Plant cell and molecular biology
- Animal cell and molecular biology
- Oncology and carcinogenesis not elsewhere classified
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