10.26181/11991462.v2
John La-Marca
John
La-Marca
Helena Richardson
Helena
Richardson
Two-Faced: Roles of JNK Signalling During Tumourigenesis in the Drosophila Model
La Trobe
2022
JNK regulation
JNK pathway activation
Cancer
Drosophila melanogaster
Tumourigenesis
Ras
Apoptosis
JNK
Drosophila
Scrib
Cell Biology
Cell Development, Proliferation and Death
Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
Genetics
Molecular Biology
Animal Cell and Molecular Biology
Cancer
2022-11-10 00:02:19
Journal contribution
https://opal.latrobe.edu.au/articles/journal_contribution/Two-Faced_Roles_of_JNK_Signalling_During_Tumourigenesis_in_the_Drosophila_Model/11991462
The highly conserved c-Jun N-terminal Kinase (JNK) signalling pathway has
many functions, regulating a diversity of processes: from cell movement
during embryogenesis to the stress response of cells after
environmental insults. Studies modelling cancer using the vinegar fly,
Drosophila melanogaster, have identified both pro- and anti-tumourigenic
roles for JNK signalling, depending on context. As a tumour suppressor,
JNK signalling commonly is activated by conserved Tumour Necrosis
Factor (TNF) signalling, which promotes the caspase-mediated death of
tumourigenic cells. JNK pathway activation can also occur via actin
cytoskeleton alterations, and after cellular damage inflicted by
reactive oxygen species (ROS). Additionally, JNK signalling frequently
acts in concert with Salvador-Warts-Hippo (SWH) signalling – either
upstream of or parallel to this potent growth-suppressing pathway. As a
tumour promoter, JNK signalling is co-opted by cells expressing
activated Ras-MAPK signalling (among other pathways), and used to drive
cell morphological changes, induce invasive behaviours, block
differentiation, and enable persistent cell proliferation. Furthermore,
JNK is capable of non-autonomous influences within tumour microenvironments by effecting the transcription of various cell growth-
and proliferation-promoting molecules. In this review, we discuss these
aspects of JNK signalling in Drosophila tumourigenesis models, and
highlight recent publications that have expanded our knowledge of this
important and versatile pathway.<br>