Shafee, Thomas Lay, Fung T. Hulett, Mark D. ANDERSON, MARILYN Extreme convergent evolution in defensin proteins & quantitative maps of their sequence space <b><u>Poster presented at</u></b><div><u>SMBE 2016</u></div><div><u>Gordon AMPs 2017</u><div><br></div><div><div>Defensins are small, charged, disulphide-rich</div><div>eukaryotic proteins with diverse sequences, structures, and</div><div>functions. Their antimicrobial activities are of particular interest</div><div>for protecting crops and humans from pathogens.</div><div>They have been traditionally treated as a single superfamily.</div><div>However, we present evidence that there exist two independent</div><div>evolutionary origins of defensins, based on their secondary</div><div>structure element order, disulphide topology, and tertiary</div><div>structures. These two superfamilies, the cis-defensins and transdefensins,</div><div>exhibit some of the most extensive convergent</div><div>evolution of protein sequence, structure and function.</div><div>We have developed new methods of sequence alignment and</div><div>analysis to overcome the difficulties of investigating such short</div><div>and divergent sequences. Multivariate analysis of protein</div><div>sequence space allows grouping of defensins into naturally</div><div>occurring clusters which describe the residue properties that</div><div>separate phyla and functions. It can be further used to design</div><div>synthetic, cluster-central, archetypal defensin sequences.</div></div></div><p></p> convergent evolution;defensin;Defensin families;defensin subfamilies;Sequence Space;protein sequence space;Molecular Evolution;Proteins and Peptides 2020-03-01
    https://opal.latrobe.edu.au/articles/poster/Extreme_convergent_evolution_in_defensin_proteins_quantitative_maps_of_their_sequence_space/11918736
10.26181/5e5b7468351b0